Interventions include discontinuation of Sodium Chloride Injection, USP administration, dose reduction, and other measures as indicated for the specific clinical constellation (e.g., monitoring of fluid balance, electrolyte concentrations and acid base balance). if you have any concerns. This rarely happens as Sodium Chloride Injection and Sodium Chloride Intravenous Infusion The solution contact materials do not contain PVC, DEHP, or other plasticizers. In very low birth weight infants, excessive or rapid administration of Sodium Chloride Injection, USP may result in increased serum osmolality and risk of intracerebral hemorrhage. The equipment should be primed with the solution in order to prevent air entering the system. If you have any concerns about taking this medicine, ask your doctor or pharmacist. Drugs leading to an increased vasopressin effect. with these terms and conditions. Tell your doctor if you are taking any other medicines, including any that you buy Preparation for Administration 4. If use cannot be avoided, monitor fluid balance, electrolyte concentrations, and acid base balance, as needed and especially during prolonged use. with your doctor. Special warnings and precautions for use). To avoid complications, monitor serum sodium and chloride concentrations, fluid status, acid-base balance, and signs of neurologic complications. d. Discard unit if leaks, particles or cloudiness are evident. Nursing Mothers: It is not known whether this drug is excreted in human milk. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user, and would normally not be longer than 24 hours at 2 to 8°C, unless reconstitution has taken place in controlled and validated aseptic conditions. However, some may be serious and need medical In case of adverse reaction, infusion must be stopped immediately. Some medicines may affect the way sodium chloride works. Lithium Renal sodium and lithium clearance may be increased during administration of 0.9% Sodium Chloride Injection, USP. It is not known whether this drug is present in human milk. the management of other conditions that are not mentioned above. Additives may be introduced before infusion or during infusion through the injection site. Sodium chloride 0.9% solution as Sodium Chloride Injection and Sodium Chloride Intravenous Infusion is a clear, colourless solution contained in plastic ampoules or vials. This leaflet answers some common questions about Sodium Chloride Injection and Sodium To Open Use sterile material for preparation and administration. at the same time. Sodium Chloride 0.9% intravenous infusion has a tonicity of 308 mOsm/l (approx.). meningitis, intracranial bleeding, cerebral contusion and brain oedema) are at particular risk of the severe and life-threatening brain swelling caused by acute hyponatraemia. Consult with a pharmacist, if available. All medicines have benefits and risks. Metabolism and nutrition disorders: Hypernatremia, hyponatremia, hyperchloremic metabolic acidosis. It does not contain all the available information. Last updated on Aug 1, 2020. Dose (mEq sodium) = [desired serum sodium (mEq/L) - actual serum sodium (mEq/L)] x total body water (TBW). After addition, if there is a discoloration and/or the appearance of precipitates, insoluble complexes or crystals, do not use. Other Drugs that Increase the Risk of Hyponatremia Avoid excessive heat. Composition, osmolarity, and ionic concentration are shown below: 0.9% Sodium Chloride Injection, USP contains 9 g/L Sodium Chloride, USP (NaCl) with an … If you notice The recommended dosage for treatment of isotonic extracellular dehydration and sodium depletion is: • For babies and children: 20 to 100 ml per 24h and per kg of body weight, depending of the age and the total body mass. Other side effects not listed above may also occur in some patients. A serum sodium concentration of 145 to 150 mEq/L may be targeted as this typically coincides with the desired reduction in intracranial pressure. Do not use if the packaging is torn or shows signs of tampering. Brief exposure up to 40°C (104°F) does not adversely affect the product. If leaks are found discard unit as sterility or function may be impaired. General adverse effects of sodium excess in the body include nausea, vomiting, diarrhea, abdominal cramps, thirst, reduced salivation and lacrimation, sweating, fever, tachycardia, hypertension, renal failure, peripheral and pulmonary oedema, respiratory arrest, headache, dizziness, restlessness, irritability, weakness, muscular twitching and rigidity, convulsions, coma, and death. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. between patient and physician/doctor and the medical advice they may provide. Details of the use of the set can be recorded – record labels are available from Baxter Healthcare Ltd. Chemical and physical stability of any additive medication at the pH of the Sodium chloride 0.9 Infusion in the VIAFLEX container should be established prior to use. Special clinical monitoring is required at the beginning of any intravenous infusion. Do not leave the syringe and needle in the port once the medication has been injected. Grip top of blue frangible connector between thumb and forefinger of one hand. Avoid Sodium Chloride Injection, USP in patients with severe renal impairment or conditions that may cause sodium and/or potassium retention, fluid overload, or edema. Adding medication or using an incorrect administration technique might cause the appearance of fever reactions due to the possible introduction of pyrogens. burns, surgery, head-injury, infections), and concomitant therapy should be determined by the consulting physician experienced in paediatric intravenous fluid therapy (see sections 4.4. and 4.8).